Innovative work in the field of extracellular chaperones from the Bourboulia Lab has resulted in the identification of TIMP2 (Bourboulia & Stetler-Stevenson, Semin Can Biol 2010), an endogenous inhibitor of angiogenesis and matrix proteolysis, as  (a) the first secretory co-chaperone of extracellular molecular chaperone HSP90 (eHSP90) (Baker-Williams et al., Cell Rep 2019; Votra et al., MIMB, 2023) and   (b) a phosphoprotein and extracellular substrate of secreted tyrosine kinase c-Src (Sánchez-Pozo et al., iScience 2018; Truman et al., JBC 2021). Bourboulia’s recent work has demonstrated a new paradigm for Src regulation of the extracellular milieu, particular for disease states where c-Src is hyperactive (Backe et al., Cell Rep 2023; Omini et al., STAR Prot 2023).