Articles

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Backe SJ, Votra SD, Stokes MP, Sebestyén E, Castelli M, Torielli L, Colombo G, Woodford MR, Mollapour M, Bourboulia D. PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling. Cell Rep. 2023 Jun 27;42(6):112539. doi: 10.1016/j.celrep.2023.112539. Epub 2023 May 25. PubMed PMID: 37243593; NIHMSID:NIHMS1912762.

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Woodford MR, Backe SJ, Wengert LA, Dunn DM, Bourboulia D, Mollapour M. Hsp90 chaperone code and the tumor suppressor VHL cooperatively regulate the mitotic checkpoint. Cell Stress Chaperones. 2021 Sep 29. doi:
10.1007/s12192-021-01240-2. Epub ahead of print. PMID: 34586601.

 

Truman AW, Bourboulia D, Mollapour M. Decrypting the chaperone code. J Biol Chem. 2021 Jan-Jun;296:100293. doi: 10.1016/j.jbc.2021.100293. Epub 2021 Feb 16.PMID: 33837727

 

Baker-Williams AJ, Hashmi F, Budzyński MA, Woodford MR, Gleicher S, HimanenSV, Makedon AM, Friedman D, Cortes S, Namek S, Stetler-Stevenson WG, Bratslavsky G, Bah A, Mollapour M, Sistonen L, Bourboulia D. Co-chaperones TIMP2 and AHA1Competitively Regulate Extracellular HSP90:Client MMP2 Activity and MatrixProteolysis. Cell Rep. 2019 Aug 13;28(7):1894-1906.e6. doi:10.1016/j.celrep.2019.07.045. PubMed PMID: 31412254.

 

Sánchez-Pozo J, Baker-Williams AJ, Woodford MR, Bullard R, Wei B, Mollapour M, Stetler-Stevenson WG, Bratslavsky G, Bourboulia D. Extracellular Phosphorylation of TIMP-2 by Secreted c-Src Tyrosine Kinase Controls MMP-2 activity. iScience 2018, 1, 87-96. 10.1016/j.isci.2018.02.004

 

Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, Bratslavsky G, Mollapour M. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nat Commun. 2016 Jun 29;7:12037, PMID: 27353360

 

Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M. c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. Cell Rep. 2015 Aug 11;12(6):1006-1018, PMID: 26235616

 

Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson WG, Bratslavsky G, Trepel JB, Prodromou C, Neckers L. Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors. Mol Cell. 2014 Jan 23;53(2):317-329, PMID: 24462205

 

Han HY, Bourboulia D, Jensen-Taubman S, Isaac B, Wei B and Stetler-Stevenson WG. An endogenous inhibitor of angiogenesis inversely correlates with side population phenotype and function in human lung cancer cells. Oncogene 2014, 33, 1198-1206, advance online publication, March 11, 2013, PMID: 23474755

 

Bourboulia D, Han H, Jensen-Taubman S, Gavil N, Isaac B, Wei B, Neckers L, Stetler-Stevenson WG. TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells. Oncotarget. 2013 Jan;4(1):166-176, PMID: 23371049

 

Guedez L, Jensen-Taubman S, Bourboulia D, Kwityn CJ, Wei B, Caterina J, Stetler-Stevenson WG. TIMP-2 targets tumor-associated myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesis. J Immunother. 2012 Jul;35(6):502-512, PMID: 22735808

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Bourboulia D, Jensen-Taubman S, Rittler MR, Han HY, Chatterjee T, Wei B and Stetler-Stevenson WG. Endogenous angiogenesis inhibitor blocks tumor growth via direct and indirect effects on tumor microenvironment. Am J Pathol. 2011, 179, 2589-2600, PMID: 21933655

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Reviews/Book chapters/Commentaries

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Woodford MR, Bourboulia D, Mollapour M. Epichaperomics reveals dysfunctional chaperone protein networks. Nat Commun. 2023 Aug 22;14(1):5084. doi: 10.1038/s41467-023-40713-z. PMID: 37607923; PMCID: PMC10444821.

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Bourboulia D, Woodford MR, Mollapour M. Extracellular HSP90 warms up integrins for an irisin workout. Cell Metab. 2023 Jul 11;35(7):1099-1100. doi: 10.1016/j.cmet.2023.06.002. Epub 2023 Jun 15. PMID: 37327790.

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Votra SD, Alsalih D, Bourboulia D. Methods to Assess the Impact of Hsp90 Chaperone Function on Extracellular Client MMP2 Activity. Methods Mol Biol.2023;2693:221-232. doi: 10.1007/978-1-0716-3342-7_17. PMID: 37540438.

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Sager RA, Khan F, Toneatto L, Votra SD, Backe SJ, Woodford MR, Mollapour M, Bourboulia D. Targeting extracellular Hsp90: A unique frontier against cancer. Front Mol Biosci. 2022 Aug 17;9:982593. doi: 10.3389/fmolb.2022.982593. PMID:
36060252; PMCID: PMC9428293.

 

Sager RA, Backe SJ, Ahanin E, Smith G, Nsouli I, Woodford MR, Bratslavsky G, Bourboulia D, Mollapour M. Therapeutic potential of CDK4/6 inhibitors in renal cell carcinoma. Nat Rev Urol. 2022 May;19(5):305-320. doi: 10.1038/s41585-022-00571-8. Epub 2022 Mar 9. PMID: 35264774; PMCID: PMC9306014.

 

Hashmi F, Mollapour M, Bratslavsky G, Bourboulia D. MMPs, tyrosine kinase signaling and extracellular matrix proteolysis in kidney cancer. Urol Oncol. 2020 May 31:S1078-1439(20)30194-0. doi: 10.1016/j.urolonc.2020.04.034. Epub ahead of print. PMID: 32487351

 

Cortes S, Baker-Williams AJ, Mollapour M, Bourboulia D. Detection and Analysis of Extracellular Hsp90 (eHsp90). Methods Mol Biol. 2018;1709:321-329. doi: 10.1007/978-1-4939-7477-1_23. PMID: 29177669

 

Chehab M, Caza T, Skotnicki K, Landas S, Bratslavsky G, Mollapour M, Bourboulia D. Targeting Hsp90 in urothelial carcinoma. Oncotarget. 2015 Apr 20;6(11):8454-8473, PMID: 25909217

 

Remillard T., Bratslavsky G., Jensen-Taubman S., Stetler-Stevenson W.G. and Bourboulia D. Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironment. Molecular and Cellular Therapies 2014, 2, 17, PMID: 26056585

 

Abouelleil M, Bratslavsky G and Bourboulia D. Prostate Cancer Biomarkers – A Bench to Bedside perspective. Cancer Science and Research: Open Access 2014, 1, 3

 

Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L, Mollapour M. Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity. Future Med Chem. 2013 Jun;5(9):1059-1071, PMID: 23734688

 

Stetler-Stevenson W, Bourboulia D, Guedez L and Jensen-Taubman S. Anti-tumoral Properties of Endogenous Angiogenesis Inhibitors: A Case for Continued TIMP-2 Preclinical Development. Current Angiogenesis 2012, 1, 148-156

 

Bourboulia D, Jensen-Taubman S and Stetler-Stevenson WG. TIMP-2 An Endogenous Angiogenesis Inhibitor with Distinct Antitumoral Properties. Treatment Strategies-Hemat. 2012, 2, 31-35

 

Bourboulia D, and Stetler-Stevenson WG. Matrix MetalloProteinases (MMPs) and Tissue Inhibitors of MetalloProteinases (TIMPs): positive and negative regulators in tumor cell adhesion. Semin Cancer Biol. 2010, 20, 161-168. PMID: 20470890