Group members

Dimitra Bourboulia,

Principal Investigator

Dr. Bourboulia received her B.S. in Clinical Diagnostic Laboratories, Technological Educational Institute of Thessaly, Greece. She earned her M.Sc. in Applied Molecular Biology of Infectious Diseases from London School of Hygiene and Tropical Medicine, University of London, England, UK. She then received her Ph.D. in Oncology from UCL, University of London where she worked on human oncogenic and immunodeficiency viruses in Prof. Robin Weiss and Prof. Chris Boshoff laboratories.

 

In 2007, Dr. Bourboulia moved to the National Institutes of Health where she jointed the laboratory of Dr. William G. Stetler-Stevenson at the National Cancer Institute in Bethesda, Maryland. There she studied the function of TIMP-2, an endogenous angiogenesis inhibitor and one of the natural inhibitors of extracellular matrix metalloproteinases (MMPs) focusing primarily on MMP-2 independent functions in various types of cancer.

 

In 2013, Dr. Bourboulia joined the Department of Urology at State University of New York Upstate Medical University.

Fiza Hashmi,

Graduate Student

I received my undergraduate degree from the University of Virginia, B.A., in English Literature and then went to complete a Master’s Degree in Physiology and Biophysics from the Virginia Commonwealth University. I worked in the laboratory of Liya Qiao, at Virginia Commonwealth University, where I studied the effects of brain-derived neurotrophic factor (BDNF) and its signaling pathway on sensory neuronal activation and visceral hypersensitivity during colitis and gastrointestinal inflammation.

 

Publications

 

  1. Woodford MR, Baker-Williams AJ, Sager RA, Backe SJ, Blanden AR, Hashmi F,
    Kancherla P, Gori A, Loiselle DR, Castelli M, Serapian SA, Colombo G, Haystead
    TA, Jensen SM, Stetler-Stevenson WG, Loh SN, Schmidt LS, Linehan WM, Bah A,
    Bourboulia D, Bratslavsky G, Mollapour M. The tumor suppressor folliculin
    inhibits lactate dehydrogenase A and regulates the Warburg effect. Nat Struct
    Mol Biol. 2021 Aug;28(8):662-670. doi: 10.1038/s41594-021-00633-2. Epub 2021 Aug
    11. PMID: 34381247.

  2. Hashmi F, Mollapour M, Bratslavsky G, Bourboulia D. MMPs, tyrosine kinase signaling and extracellular matrix proteolysis in kidney cancer. Urol Oncol. 2020 May 31:S1078-1439(20)30194-0. doi: 10.1016/j.urolonc.2020.04.034. Epub ahead of print. PMID: 32487351

  3. Baker-Williams AJ, Hashmi F, Budzyński MA, Woodford MR, Gleicher S, Himanen
    SV, Makedon AM, Friedman D, Cortes S, Namek S, Stetler-Stevenson WG, Bratslavsky 
    G, Bah A, Mollapour M, Sistonen L, Bourboulia D. Co-chaperones TIMP2 and AHA1
    Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix
    Proteolysis. Cell Rep. 2019 Aug 13;28(7):1894-1906.e6. doi:
    10.1016/j.celrep.2019.07.045. PubMed PMID: 31412254.

  4. Shen S, Al-Thumairy HW, Hashmi F, Qiao LY. Regulation of transient receptor
    potential cation channel subfamily V1 protein synthesis by the phosphoinositide
    3-kinase/Akt pathway in colonic hypersensitivity. Exp Neurol. 2017
    Sep;295:104-115. doi: 10.1016/j.expneurol.2017.06.007. Epub 2017 Jun 3. PubMed
    PMID: 28587873; PubMed Central PMCID: PMC5535076.

  5. Hashmi F, Liu M, Shen S, Qiao LY. EXPRESS: Phospholipase C gamma mediates
    endogenous brain-derived neurotrophic factor - regulated calcitonin gene-related 
    peptide expression in colitis - induced visceral pain. Mol Pain. 2016 Jun 15;12. 
    pii: 1744806916657088. doi: 10.1177/1744806916657088. Print 2016. PubMed PMID:
    27306412; PubMed Central PMCID: PMC4955977. 

  6. Xia C, Shen S, Hashmi F, Qiao LY. Colitis-induced bladder afferent neuronal
    activation is regulated by BDNF through PLCγ pathway. Exp Neurol. 2016 Nov;285(Pt
    B):126-135. doi: 10.1016/j.expneurol.2015.12.006. Epub 2015 Dec 11. PubMed PMID: 
    26687970; PubMed Central PMCID: PMC4903097.

  7. Zhou Y, Liu M, Li J, Hashmi F, Mao Z, Zhang N, Zhou L, Lv W, Zheng J, Nie X,
    Li C. Impact of V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 Gene
    Polymorphisms Upon Susceptibility to Autoimmune Diseases: A Meta-Analysis.
    Medicine (Baltimore). 2015 Jun;94(22):e923. doi: 10.1097/MD.0000000000000923.
    PubMed PMID: 26039128; PubMed Central PMCID: PMC4616355.