Dimitra Bourboulia,
Principal Investigator
​
Dr. Bourboulia received her B.S. in Clinical Diagnostic Laboratories, Technological Educational Institute of Thessaly, Greece. She earned her M.Sc. in Applied Molecular Biology of Infectious Diseases from London School of Hygiene and Tropical Medicine, University of London, England, UK. She then received her Ph.D. in Oncology from UCL, University of London where she worked on human oncogenic and immunodeficiency viruses in Prof. Robin Weiss and Prof. Chris Boshoff laboratories.
In 2007, Dr. Bourboulia moved to the National Institutes of Health where she jointed the laboratory of Dr. William G. Stetler-Stevenson at the National Cancer Institute in Bethesda, Maryland. There she studied the function of TIMP-2, an endogenous angiogenesis inhibitor and one of the natural inhibitors of extracellular matrix metalloproteinases (MMPs) focusing primarily on MMP-2 independent functions in various types of cancer.
In 2013, Dr. Bourboulia joined the Department of Urology at State University of New York Upstate Medical University.
Michael P. Omini,
First year PhD student​
Michael received his BSc. in Biochemistry from University of Victoria, British Columbia. He earned his MSc. in Biotechnology from Syracuse University. He joined the Bourboulia Lab and the PhD Graduate Program in Biochemistry and Molecular Biology at Upstate Medical University in August 2024.
​
Publications
Omini MP, Alsalih D, Votra SD, Bourboulia D. Protocol to characterize extracellular c-Src tyrosine kinase function through substrate interaction and phosphorylation. STAR Protoc. 2023 Dec 15;4(4):102755. doi:10.1016/j.xpro.2023.102755. Epub 2023 Dec 2. PMID: 38043058; PMCID: PMC10701435.
SarahBeth D. Votra,
Research Support Specialist, Senior
SarahBeth participates in assigned scientific research projects and manages the daily laboratory operations.
​
Publications
1: Omini MP, Alsalih D, Votra SD, Bourboulia D. Protocol to characterize extracellular c-Src tyrosine kinase function through substrate interaction and phosphorylation. STAR Protoc. 2023 Dec 15;4(4):102755. doi:10.1016/j.xpro.2023.102755. Epub 2023 Dec 2. PMID: 38043058; PMCID: PMC10701435.
2: Votra SD, Alsalih D, Bourboulia D. Methods to Assess the Impact of Hsp90 Chaperone Function on Extracellular Client MMP2 Activity. Methods Mol Biol. 2023;2693:221-232. doi: 10.1007/978-1-0716-3342-7_17. PMID: 37540438; PMCID:PMC10594791.
3: Backe SJ, Votra SD, Stokes MP, Sebestyén E, Castelli M, Torielli L, Colombo G, Woodford MR, Mollapour M, Bourboulia D. PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling. Cell Rep. 2023 Jun 27;42(6):112539. doi:10.1016/j.celrep.2023.112539. Epub 2023 May 25. PMID: 37243593; PMCID:
PMC10569185.
4: Sager RA, Khan F, Toneatto L, Votra SD, Backe SJ, Woodford MR, Mollapour M, Bourboulia D. Targeting extracellular Hsp90: A unique frontier against cancer. Front Mol Biosci. 2022 Aug 17;9:982593. doi: 10.3389/fmolb.2022.982593. PMID:36060252; PMCID: PMC9428293.
​