Associate Professor, Urology

Associate Professor, Biochemistry and Molecular Biology

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Research Programs and Affiliations
Biomedical Sciences Program
Urology

Education & Fellowships
Fellowship: National Cancer Institute, NIH, Bethesda, MD, 2013
Fellowship: University of London, UK, 2007
PhD: University of London, UK, 2004

Previous Appointments
National Institutes of Health, 2007–2013
University of London, UK, 1999–2007

Research Interests
Extracellular kinase signaling
Extracellular chaperone function
Targeting extracellular signaling networks in urological cancers

Associations/Memberships
American Society for Matrix Biology (ASMB)

International Proteolysis Society (IPS)

Cell Stress Society International, Inc. (CSSI)

Languages Spoken (Other Than English)
Greek

Research Abstract
Research in my laboratory focuses on understanding mechanisms that regulate the extracellular HSP90 (eHSP90) chaperone machinery. Our studies have shown that similar to cytosolic HSP90, co-chaperones and post-translational modifications regulate the eHSP90 system. We have demonstrated that secreted TIMP2 and AHA act competitively to modulate the eHSP90 client MMP2 binding and activity, affecting matrix degradation. Our earlier work reported on the role of cSrc regulating TIMP2 inhibitory function towards MMP2-mediated proteolysis via phosphorylation. Our recent work has explored the broader role of cSrc in extracellular phosphorylation and how this influences the fate of the tumor microenvironment through eHSP90. Collectively, our findings offer new insights into the significant role of eHSP90 and its regulators in an extracellular mechanism that intertwines kinase-driven signaling and matrix proteolysis.

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ORCHID ID

https://orcid.org/0000-0002-8567-2775

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Scopus Profile

https://www.scopus.com/authid/detail.uri?authorId=6603388238